Discovering
the Next Generation of Cancer Therapeutics

Cleave Biosciences is focused on novel targets in cellular protein homeostasis pathways. Controlled largely by two distinct systems – the ubiquitin proteasome system and the autophagy system, these pathways are utilized by cancer cells for their growth and survival.

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Ubiquitin Proteasome System

The ubiquitin proteasome system controls the half-lives of many short lived regulatory proteins that are important for cancer cell survival and proliferation.

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Autophagy System

Recent findings have revealed a role for autophagy as a survival pathway in late-stage, aggressive cancers.

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