The AAA (ATPases Associated with diverse cellular Activities) ATPase family of enzymes is involved in a wide variety of fundamental cellular processes including protein homeostasis, transcriptional and translational control, DNA replication, membrane fusion, cell division and apoptosis. AAA ATPases are mechano-enzymes that use the energy derived from ATP hydrolysis to reshape protein/protein, protein/membrane and protein/DNA/RNA complexes. Several AAA ATPases are known to play important roles in cancer biology and present the opportunity to discover novel drugs that will have a differentiated mechanism of action compared to other commonly targeted protein classes such as protein kinases. Given the success of developing a small molecule inhibitor to p97 (CB-5083), Cleave Biosciences is currently conducting drug discovery efforts targeting several AAA proteins as oncology targets. Our aim is to build a pipeline of clinical candidate molecules for novel AAA targets.